Cola Wars Essay Example | Topics and Well Written Essays - 1500 words

Cola Wars - Essay Example Coca-Cola intensified its marketing effort from 74 million dollars to 1818 million dollars in a span of 4 years (1980-1984). Pepsi, on the other hand, also intensified its advertising from 66 million dollars to 125 million dollars during the same period. Another change in management style is the introduction of new products. Coca-Cola introduced eleven new products and Pepsi introduced thirteen new products. The two also increased their types of packaging sizes and they offered more than ten major brands. Another change in management of the two bodies is seen in the two venturing into new business areas, for instance, Coca-Cola has expanded to North America, Europe, and Asia. The Pepsi challenge in Dallas saw Pepsi eroding coke’s market, this in turn had Coca-Cola obtaining flexibility by having the franchising bottle contract approved and this boosted it past Pepsi maintaining the lead (Yoffie, 2004). There have been changes in the carbonated soft drink environment. For insta nce, the growth rate of the market size was predicted to decelerate. This is due to the cropping up of other non-alcoholic sectors: coffee, tea, energy drinks, bottled water, and sports drinks. This has caused market prices stagnation. Growth rate is decelerating due to the saturation of the market. This has made the soft drink companies look for alternative markets like bottled water, sports drinks, snacks and confections. Looking at the financial statements of the two bodies, it is clear the industry competition is high but the growth is stunted. Expanding of product lines have although kept their quick ratios inside a reasonable range. The sales and income trend is seen to be stagnant. Varying societal alarms, attitudes,... There have been changes in the carbonated soft drink environment. The growth rate of the market size was predicted to decelerate. This is due to the cropping up of other non-alcoholic sectors: coffee, tea, energy drinks, bottled water, and sports drinks. This has caused market prices stagnation. The growth rate is decelerating due to the saturation of the market. This has made the soft drink companies look for alternative markets like bottled water, sports drinks, snacks, and confections. Looking at the financial statements of the two bodies, it is clear the industry competition is high but the growth is stunted. Expanding of product lines have although kept their quick ratios inside a reasonable range. The sales and income trend is seen to be stagnant. Varying societal alarms, attitudes, and lifestyles are significant trends that are affecting the industry. Individuals are becoming more cognizant of their health - rise in obesity, not active lifestyles are a potential threat to the industry. Much of the success of these two companies can be attributed to them having an attitude that is progressive to the current competitive environment. In addition, their ability to adapt new technologies in production, packaging, and distribution gives them the opportunity to cater to the needs of the consumers more precisely and immediately than before. They do this in a way that they can still keep up with the market that is changing and the changing trends and maintain the capability to fine-tune with the changing market.

Hear My Cry Essay Example for Free

Hear My Cry Essay Stacey feels responsible for his younger brothers and sister and feels the need to protect them: Stacey glowered at T. J. a moment longer, then walked swiftly to Little Man and put his long arm around his shoulders saying softly, Come on, Man. It aint gonna happen no more, least not for a long while. I promise you that. Stacey is not only loyal to his family but also loyal to his friends. When he is faced with the decision to either be truthful to his mother or face a punishment as a result of being loyal to T. J. he chooses loyalty and therefore suffers the consequences. The society the children live in forces them to mature much more rapidly than in our society. Stacey is very mature and he is well aware of the differences between right and wrong: Despite any effort to persuade Stacey otherwise, when Mama came home he confessed that he had been fighting T. J. at the Wallace store and that Mr Morrison had stopped it. He stood awkwardly before her, disclosing only those things he could honourably mention. T. J. is Staceys best friend. He is very self-centred and is loyal to no one except himself. He seems to have no conscience and is very sly: At first T. J.wouldnt do it, but then he seen Miz Logan startin toward em and he slipped Stacey the notes Jeremy is an exception to the rule. He is a white boy but he disobeys his parents and continues to socialise with the black children. This even surprises the Logan children: It was only then that I realized that Jeremy never rode the bus, no matter how bad the weather. To help us visualise the setting of the novel Mildred D. Taylor uses occasional light, evocative description. She uses just enough for us to understand the image she is trying to portray without using too much which could cause us to loose interest. These short paragraphs of description are very effective, as she does not tell us directly what the scene is like but through similes and metaphors: Before us the narrow, sun-splotched road wound like a lazy red serpent dividing the high forest bank of quiet, old trees on the left from the cotton field, forested by giant green and purple stalks, on the right. The Difference between the Great Faith school for black students and the Jefferson Davis school for white students is acute. The Great Faith Elementary and Secondary School was a dismal end to an hours journey. Consisting of four weather beaten wooden houses on stilts of brick, 320 students, 7 teachers, a principal, a caretaker, and the caretakers cow, which kept the wide crab grass lawn sufficiently clipped in Spring and Summer. Jefferson Davis County School, a long white wooden building looming in the distance. Behind the building was a wide sports field around which were scattered rows of tiered gray-looking benches. The Jefferson Davis School for White Students gives an image of wealth and prosperity in comparison to the Great Faith school for Black students. The Logan Household is warm and inviting. The features shown in the house show that the Logan family were very skilful people. They seem to be a lot wealthier than other black people at this time: The furniture, a mixture of Logan-crafted walnut and oak, included a walnut bed whose ornate headboard rose halfway up the wall to meet the high ceiling The theme of this novel is racism and discrimination towards the black people at this time. There are many occasions in the first four chapters alone which express this racism. The most white people feel they are superior to black people in every way. They feel that if a black person steps out of line by doing the slightest thing they have the right to punish or even murder them. They seem to have no hesitation about taking the life of a black person as they feel black people are there to be taken advantage of Something as simple as saying something offensive to a white man: Mr Barnette says, you callin me a liar, boy? And Mr Tatum says, Yessuh, I guess I is! Could end up with a black man being severely punished by a gang of white night men: Tarred and feathered him! T. J. announced hastily. Poured the blackest tar they could find all over him,and plastered him with chicken feathers. The children cannot understand why the white and blacks are separated; however they are forced to understand as a matter of life and death. They are robbed of their childhood innocence long before they should be due to the dangers they would face if they stepped out of line. The author is also trying to put across the message that because of the discrimination towards the black people they live in extreme poverty. The Logans are better off than most black families as they own land, however they need money so badly that the father is forced to work away from home on the railroads for money. The schools are given books for the first time however, they are not the long awaited books they were hoping for, but torn worthless books which were no use to them. In concluding, Mildred D. Taylor has successfully portrayed the hardships the black population of the southern states of America, had to endure in the early 1930s. In the first four introductory chapters, she set the scene using descriptive tactics. She introduced us to most of the main characters and told us a bit about their physical appearance and their personality. And she most importantly explained to us the difficulties the Logan family and generally, all black families faced, due to their race and how unfair society was towards them. We learn how white people took the law onto themselves, carrying out vindictive murders at the drop of the hat. Even in the first four chapters, Mildred D. Taylor has evoked sympathy for the black people. By Emma-Jane Reilly 11E Mr Devlin! Show preview only The above preview is unformatted text This student written piece of work is one of many that can be found in our GCSE Mildred Taylor section.

The chemistry of drug metabolism

The chemistry of drug metabolism Introduction To describe and explain the chemistry of drug metabolism a basic foundation of knowledge is needed to understand the concepts. Metabolism is one of the methods for analysing the effect of drugs or xenobiotics on the body. It is basically a process of converting lipophilic drugs into more hydrophilic drugs to decrease pharmacological effect and increase subsequent hepatic or renal elimination. So it is essentially a process of inactivation and detoxification of a drug and subsequent elimination of the metabolite formed. The basic knowledge involves the all time classical reactions such as oxidation and reduction and those more advanced reactions including glucuronidation and sulfation. Despite energy being needed to drive such reactions to be in favour, metabolism cannot occur without the complex nature of enzymes catalysing the process. However, metabolism of drugs in human is not solely dependent on the enzymes alone it can be affected by natural micro flora in the small intestines. In an in vitro experiment conducted on ranitidine, it was found that N-oxide was cleaved and is therefore a source of drug metabolism. An alteration in the population of micro flora can affect the of drugs efficacy this is a source of interaction between antibiotics and Microgynon ®. Furthermore, some drugs are bioactivated by metabolism to form active metabolites with a desirable pharmacological function i.e. prodrugs. Unfortunately metabolism can transform an inactive drug or xenobiotic into a biologically active compound which can be carcinogenic to humans. Phenol is a readily formed metabolite of benzene metabolism before catechol and hydroquinone 3,6 which poses a major health concern for humans because it can cause acute myelogenous leukaemia 6 As the great founding father of medicine Paracelsus once said â€Å"all drugs are poison†. Therefore humans and animals have adapted many mechanisms for detoxifying xenobiotics, and these processes are divided into two phases phase I and phase II. It is important to bear in mind that some phase II reactions can occur without phase I metabolism, but phase I and phase II reactions are complimentary and not mutually exclusive. This report describes the chemical reactions of drug metabolism and explains how they occur in vivo. 3.0 Phase 1 Phase 1 metabolism involves the direct enzyme activity on drugs P450 isoform enzymes and esterases are responsible for reduction and hydrolysis of drugs respectively. Each P450 isoenzymes genetic expression varies and can either be inhibited or induced. Knowledge of these drivers of metabolism is essential not only to optimise the use of drugs, reduce harm, maximise benefits in poly pharmacy but also to serve as a template for novel drug development10. P450 and esterase enzymes are mainly found in the liver. Phase I metabolism consists of 3 main reactions: oxidation, reduction and hydrolysis. 3.1 Oxidation 3.1.1 P450 mono oxygenase system 3.1.2 Other oxidation reactions 3.2 Reduction reactions Reduction reactions are mainly interconversion reactions that occur in azo, nitro and epoxide groups and conversion of carbonyl to its corresponding alcohol. Reduction reactions are carried out in the body by P450 isoenzymes, NADH/NADPH reduction systems, carbonyl reductase or aldo-ketone reductase. Azo compounds are generally used in pharmaceutical and cosmetic products. Reduction of an azo group is a classical example of a reduction metabolic reaction. This reaction occurs in the presence of other enzymes and is inhibited in the presence of molecular oxygen. Mechanism of Azo reduction Azo reduction can also occur in the presence of NADH/NADPH system alone within the pH range 3.5-6.08. An azo group can either be reduced by 2 hydrogens to form hydrozo compounds or 4 hydrogens to form two aromatic amines which usually results in a colour loss10 Mechanism of Nitro reduction Nitro groups also undergo reduction reactions and these are catalysed by the same NADP systems. 6 e- are donated to the NO2 to form amine functional groups as in chloramphenicol. This then undergoes acetylation conjugation in phase II metabolism. Conversion of carbonyl to corresponding alcohols Many different enzymes have been identified that catalyse carbonyl reduction of xenobiotics, but most of them catalyse other endogenous substances including sugars and prostaglandins7 Oracin, an anticancer drug with a pro-chiral carbon is metabolised by 11 ÃŽ ²-hydroxysteroid dehydrogenase type I in the microsomes. These metabolites are stereo specific to form DHO7 as shown below in figure 3.2.4. Much of what is known about Oracin metabolism is from phase II clinical trials as its not licensed for use in chemotherapy yet. Mechanism of epoxide reduction This reaction is catalysed by microsomal epoxide hydrolase, a catalytic triad that consists of His 431, Asp226 and Glu 404. Their activity is limited because of a narrow hydrophobic tunnel in the active site and water. A water molecule ionises to form a OH and H+ OH attacks the oxirane ring and thus opens it resulting in formation of vicinal dihydrodiol. This reaction is slow in vitro without acid but in this case epoxide hydrolase catalyses the reaction. Vicinal diols formed are more water soluble thereby terminating genotoxic potential. Hydrolysis Most hydrolysis reactions occur at the ester and amide functional groups, with ester more prone to hydrolysis than amide. Amides are more stable than esters because nitrogen is similar to carbon in size, but less electronegative than oxygen so electrons are pulled into the carbonyl Ï€ electron systems which stabilise its structure. The ease of hydrolysis of esters is used in the development of prodrugs to avoid first pass metabolism, a major problem in orally administered drugs. In vivo hydrolytic metabolism of drugs occurs in the presence of enzymes present in various parts of the body. Hydrolysis of drugs and xenobiotics is generally carried out by esterases mainly in the plasma and intestine and not by P450 systems. The blood, GI tract and liver have the highest hydrolysing capacity. The most significant hydrolysing enzymes are carboxylesterases, cholinesterases, arylesterases and serine endopeptidases. Carboxylesterase is one of the major esterases involved in drug metabolism and xenobiotic biotransformation of drugs with esters, amide and thioester functional groups. In figure 3.0 hydrolysis of ester bond results in benzoylecgonine, a carboxylic acid metabolite. But this is not the only ester group present in the structure. The group present next to the benzene can also undergo metabolism to form benzoic acid. Cocaine in the presence of heroine can generate the toxic metabolite cocaethylene in the presence of alcohol, from concomitant cocaine abuse. Carboxylesterase exists in two different forms hCE1 and hCE2. hCE1 is a more effective metabolic enzyme which transports protein to the endoplasmic reticulum and processes fatty acids and cholesterol in the liver alongside other cholesterol enzymes. The general mechanism of drug hydrolysis in esters and amides is by nucleophilic acyl substitution reactions as shown in figure 3.2.6. Minor structural differences exist between heroine and its metabolites, but their activity differs. Heroin (diamorphine) is converted by hydrolysis to 6-acetylmorphine and morphine. hCE1 mainly cleaves the 3-acetyl linkage to form 6-acetylmorphine. The 6-acetyl linkage is cleaved which later forms morphine with a phenolic -OH and secondary allylic -OH. Diloxanide furorate is a drug of choice and an antiparasitic agent for treating asymptomatic patients with E. histolytica cysts in the faeces and cryptosporidiosis, an acute intestinal amoebiaosis in HIV patients. The drug is orally administered and extensively metabolised by gastro intestinal esterase to form diloxanide and furoic acid, thereby diminishing its effectiveness. This problem is modified by using cyclodextrin that prevents excessive hydrolysis of the drug. Carboxylesterases ability to form a stable complex enhances its presence in the blood and makes it ideal for treating cocaine overdose. It is also considered that as an active site for drugs, this would make it ideal for drug discovery e.g. sarin and VX gas. 4. Phase II Conjugation pathway The phase II conjugation pathway is often a detoxification mechanism. It terminates drug pharmacological activity by changing or masking functional groups in the parent drug or phase I metabolite into a more ionic polar product which aids excretion. The processes that commonly occur in phase II metabolism can be fundamentally divided into 3 groups which are glucuronidation, sulfation and acetylation. The nature and functional group of a drug molecule will determine which one of these processes be in favour e.g. acetaminophen undergoes both glucuronidation and sulfation, however at high doses glucuronidation predominates and at low doses sulfation predominate (Airpine Choonara, 2009). 4.1. Conjugation with sugars Conjugation with various sugars is possible in nature, and novel pathways for xenobiotic metabolism are discovered frequently (Ikenakaa, Ishizakab, Miyabaraa, 2007). However the most important reaction in humans is glucuronidation. 4.1.1 Glucuronidation Glucuronidation is essentially conjugation of a substrate with ÃŽ ±-D-glucuronic acid, shown in figure 4.1.1.1. As the name suggests, glucuronic acid is a derivative of glucose with the 6th carbon being oxidised to a carboxylic acid group. This in combination with the many hydroxyl groups gives glucuronic acid a solubility of 1g/10mL in cold water, which the British Pharmacopeia would class as â€Å"freely soluble† (British Pharmacopeia Commission, 2009) Glucuronic acid is present in vivo as the co-factor uridine 5-diphosphate-glucuronic acid (UDP-glucuronic acid). The reaction of UDP-glucuronic acid with a xenobiotic substrate is catalysed by the enzyme UDP-glucuronosyltransferase (UGT) (Kaeferstein, 2009), and an example of a glucuronidation reaction is shown in figure 4.1.1.2 Figure 4.1.1.2 demonstrates how glucuronidation can occur with a xenobiotic containing an acceptor nucleophilic group (for example COOH, SH or NH2, but in this case OH) (Kaeferstein, 2009) (Sakaguchi, Green, Stock, Reger, King, 2004). The lone pair of electrons on the hydroxyl group attacks at the 1st carbon of the pyranose ring, which is activated because of the adjacent electron-withdrawing oxygens, in an SN2 nucleophilic substitution reaction. The UDP glycosidic bond is cleaved off owing to the good leaving group properties of the phosphate group, and the xenobiotic has reacted with the glucuronic acid to form a ÃŽ ²-D-glucopyranosiduronic acid conjugate. Note that the reaction is known to be SN2 because the formation of an intermediate leads to an inversion of stereochemistry at the anomeric carbon. The resulting glucuronide conjugate has improved solubility due to the hydroxyl and carboxylate groups, and is usually excreted in the urine, although there is evidence to suggest that conjugates with a high molecular weight are eliminated in the bile. However the glucuronides undergo some important reactions within the body which affects their metabolism. A spontaneous intramolecular reaction can lead to esterification of the glucuronide, as shown in figure 4.1.1.4. The newly formed ester carbonyl is capable of reacting with the N-terminal of a protein residue to form a stable imine, i.e. this can lead to irreversible protein binding. Alternatively, depending on which species the glucuronic acid is bound to, nucleophilic substitution can again occur and the xenobiotic will react with the N-terminal of the protein and regenerate free glucuronic acid (Zamek-Gliszczynski, Hoffmaster, Nezasa, Brouwer, 2006). Pharmaceutical companies may therefore try to avoid designing drugs which are predicted to be metabolised by the glucuronidation pathway, not just to increase the half-life of the drug by avoiding conjugation and excretion but also to avoid the potential side-effects that can occur as a result of protein binding, such as cirrhosis of the liver. Interestingly, glucuronidation can also lead not just to metabolites that lose their therapeutic use and are toxic, but some glucuronides can continue to be pharmacologically active and may even be more potent than their parent drug. Morphine-6-glucuronide (M6G) is one such example. M6G and morphine are both potent analgesics M6G, despite having been conjugated with a large polar molecule, still binds strongly to ÃŽ ¼ opioid receptors to provide pain relief to the same extent as morphine. Morphine-3-glucuronide, another metabolite, binds preferentially to NMDA receptors instead, and causes allodynia, myoclonus and seizures (the side-effects associated with opiate usage). Morphine and codeine are so far the only known examples of glucuronides with high activity (Kaeferstein, 2009). 4.2. Glutathione conjugation Glutathione serves as a substrate for electrophilic drugs because of the nucleophilic thiol moiety on the cysteine residue (thus glutathione can be referred to in reaction pathways as simply GSH). GSH conjugation therefore involves a nucleophilic attack of the sulphur atom onto drugs with electrophilic carbon atoms, i.e. those bound to good leaving groups such as halogens, sulphate and nitro, as well as activated carbon atoms in ring strained systems such as epoxides and ß-lactones (Zamek-Gliszczynski, Hoffmaster, Nezasa, Brouwer, 2006). Conjugation leads to a thioether bond being formed between GSH and the drug molecule. Following this reaction, conjugates are typically metabolised further to yield more polar molecules which are better excreted in the urine and bile (Zamek-Gliszczynski, Hoffmaster, Nezasa, Brouwer, 2006). Figure 4.2.4 shows the possible biotransformation reactions of a glutathione conjugate. Transpeptidase and peptidase convert glutamate to NH2 and remove glycine, respectively. NH2 is then a target for N-acetylation (mentioned in section 4.4). Alternatively, two molecules of glutathione can react together to form a disulfide bridge, in the process donating hydrogen atoms to reduce another molecule. This is usually utilised in vivo when glutathione acts as an antioxidant (Forman, Zhang, Rinna, 2009), but also plays a part in drug metabolism as seen in the denitrification of the antianginal drug, glyceryl trinitrate (GTN) in figure 4.2.5 (Ji, Anderson, Bennett, 2009). To reiterate, GSH reacts with highly electrophilic species in the body. This prevents drugs with electrophilic groups from attacking important nucleophilic centres in biological molecules, such as DNA and proteins, which could lead to toxicity. This is explored further in section 5 where the consequences of insufficient glutathione conjugation of paracetamol metabolites are looked at. 4.3. Sulfation Sulfation is one of the classical processes of phase II metabolism. It allows the biotransformation of numerous xenobiotics and metabolites from phase 1 (shown in figure 4.3.1) to be sulphate conjugates. This gives protection against toxicity or the potential toxic effects from the numerous xenobiotics and metabolites not being conjugated. It also produces more polar, more water soluble metabolites, which means they are more easily and readily excreted in urine or bile. The sulphate conjugate possesses such advantageous properties by having a low pKa, allowing an increased aqueous solubility and excretion. It is an important reaction for drugs and hormones that contain the phenolic functional group to be metabolised by conjugation to a sulphate group examples include steroid hormones, catecholamines, neurotransmitters, thyroxine, bile acids and phenolic drugs. Examples of drugs and xenobiotics with a phenolic group attached: The chemistry behind the sulfation conjugation reaction emphasizes the important key features of the system. This includes the two enzymes sulfatase and sulfotransferase, alongside the co factor 3†²-phosphoadenosine 5†²-phosphosulfate (3†²-phosphoadenylylsulfate, PAPS) which plays an important role in sulfation conjugation. The availability of PAPS and its precursor inorganic sulphate determines the reaction rate as the total amount of sulphate is limited and can be readily used up. PAPS is formed enzymatically by ATP and inorganic sulphate. The enzyme sulfotransferase transfers the active sulphate from PAPS to the xenobiotic or a phase 1 metabolite forming the sulphate conjugate (VL Verdugo D, 2004). Sulphate conjugation is a reaction principally of phenols and to a lesser extent alcohols to form highly ionic polar sulphates. Sulphate conjugation is also important for steroids because steroid sulphates are not capable of binding to their receptor and so this reduces its biological activity. Sulfation of alcohol generates a good leaving group and can be an activation process for alcohols to produce a reactive electrophilic species. Mechanism of sulfation conjugation an electrophilic substitution reaction: The oxygen of the OH has a negative inductive effect on the benzene ring so it withdraws electrons towards it making it a more reactive nucleophile It attacks the electrophilic sulphur of the sulphate group of PAPS The hydrogen of the OH bond leaves in exchange for the sulphate group and UDP acts as a good leaving group This forms the sulphate conjugate which is soluble and readily excreted via the kidneys 4.4. Acetylation Conjugation Acetylation is also an important reaction in phase II metabolism as the majority of drugs contain a primary amine functional group. It is a major route for the biotransformation of hydrazine and aromatic amines. This means that acetylation of the arylamine or phase 1 metabolites can occur more easily to reduce their biological activity (Garcia-Galan Diaz-Cruz, 2008). The limitation of acetylation is that it produces conjugates that are less water soluble (Zamek-Gliszczynski, Hoffmaster, Nezasa, Brouwer, 2006) as well as it does not work for drugs containing secondary amine groups. The aim of acetylation is to convert the primary amine moiety into an amide because amides are more stable as peptide bonds are more resistant to hydrolysis. Like glucuronidation and sulfation this reaction is highly specific because of the nature of the enzyme involved. The main players of acetylation conjugation are N-acetyltransferase and the co factor acetyl Coenzyme which is a thioester . The reactio n undergoes electrophilic substitution similar to Friedal-Craft acylation. The NH2 attached to the aromatic ring makes it much more reactive and electron donating. NAT helps to transfer the acetyl group (CH3CO) obtained from Co enzyme A (CH3COSCoA) to conjugate with the drug at the amine site forming the amide bond. H-SCo-enzyme acts as a good leaving group. Mechanism of acetylation conjugation: The lone pairs of the nitrogen of the primary amine of sulphonamide attack the carbonyl carbon of the acetyl group of the acetyl coenzyme A. In this reaction nitrogen acts as a nucleophile, donating the pair of electrons to the electrophilic carbonyl carbon. The carbonyl carbon (ÃŽ ´+) is activated by the electron withdrawing oxygen (ÃŽ ´-) making it more susceptible to nucleophilic attack. This forms a temporary tetrahedral intermediate, which falls back to form an amide bond and SH-CoA acts as a leaving group. As a result the acetyl conjugation of sulphonamide is formed, and this is readily excreted via the kidneys. 4.5 Stereo selectivity Stereo selectivity is classed as a fundamental aspect of drug metabolism ever since the tragic case of the drug thalidomide. This has provided a broader knowledge on the understanding of drugs and xenobiotics and also the importance of their stereochemistry properties. As mentioned in section 4.1.1 (glucuronidation), drug metabolism may lead to stereochemistry inversion of substrates during the various reactions that occur. An example of how the understanding of stereochemistry in xenobiotic metabolism has practical applications can be seen with the non-steroidal anti-inflammatory drug ibuprofen. It has been found that in vitro, only the S-isomer is pharmacologically active in inhibiting cyclooxygenase enzymes. However in vivo the metabolism of ibuprofen is complex, involving glucuronidation at the acyl group and hydroxylation at the 2 and 3 positions, but most importantly the metabolism of the 2 enantiomers differs because there is a unidirectional enzymatic conversion of the R-isomer to the active S-isomer. (Chang, et al., 2008). The metabolism of ibuprofen is summarised in figure 4.5.2. For this reason drug manufacturers typically produce a racemic mixture of ibuprofen for administration to patients, since the R-isomer will be converted within the body, and producing an enantiomerically pure sample would be needlessly expensive. 5. Micellaneous Amino acid conjugation is important for metabolising, solubilising and eliminating carboxylic acids through the urine because it produces very soluble conjugates. Amino acid conjugation mechanism e.g. benzoic acid (Xu, et al., 2007): The carboxylic group of the benzoic acid is first activated by ATP to the AMP ester This is then converted to the corresponding coenzyme A thioester with CoASH. These first two steps are catalysed by acyl Coenzyme A synthase enzyme The appropriate amino acid N-acyltransferase then catalyses the condensation of amino acid and Coenzyme A thioester to form the amino acid conjugate. Methylation conjugation: Even though it is not a common reaction for most drugs and xenobiotics, it is worth mentioning methylation because it is the most common biochemical reaction for endogenous compounds such as catecholamines (Strous, et al., 2009). Methylation plays a key role in the inactivation of amines such as norepinephrine, serotonin, dopamine and histamine, and is also involved in the biosynthesis of epinephrine and melatonin. A source of methyl comes from the high energy nucleotide S- adenosylmethionine (SAM) which is transported by cathecol-O- methyltransferase. However, it has been reported that methylated conjugates do not have improved water solubility (a similar disadvantage to acetylation). Methylation mechanism the nucleophilic substitution of norepinephrine: The lone pair on the electronegative oxygen of norepinephrine (R-OH) attacks the CH3 of SAM The bond between the sulphur and carbon breaks (S-C) Drug Toxicity The toxicity associated with acute paracetamol overdose is due to its metabolism processes. In the human body, paracetamol is mostly metabolised 30% by the sulfation pathway, 60% via glucuronidation and the remaining 10% being either excreted unchanged in the urine or undergoing CYP450-dependent oxidation as shown in figure 5.3 to form N-acetyl-p-benzoquinoneimine (NAPQI) (Airpine Choonara, 2009). NAPQI contains an electronically activated ring system, capable of attacking nucleophilic molecules such as N atoms in cellular macromolecules and causing cell damage. However NAPQI will preferably attack the more nucleophilic sulphur atom of glutathione and therefore will also undergo phase II metabolism to form inactive conjugates a schematic summary of the metabolism of paracetamo In overdose situations, the glutathione supply is used up as it is conjugated with the excessive NAPQI in the system. This leaves the rest of the NAPQI free to bind irreversibly to proteins in hepatic liver cells (since P450 metabolism occurs predominantly in the liver) and this cause liver necrosis. Without the detoxification capacity of the liver, the human body will typically die within 2 weeks (Airpine Choonara, 2009). With the chemistry of paracetamol metabolism in mind, it is easier to understand why some patients are classed as â€Å"high-risk† and thus more susceptible to paracetamol overdose: Recent alcohol (ethanol) consumption causes induction of the P450 enzyme involved in the formation of the NAPQI molecule; this leads to an increased quantity of NAPQI being produced and therefore the bodys supply of glutathione for conjugation is more rapidly used up leading to toxicity. Other drugs which induce the same P450 enzymes will have the same effect. Eating disorders such as anorexia nervosa lead to a poor diet and therefore decreased synthesis of glutathione in vivo, so NAPQI detoxification conjugation can be overwhelmed at lower concentrations of paracetamol consumption.

Genre Of Clowning (Theatre, Drama, Arts) :: essays research papers

The Genre Of Clowning The genre of clowning actually originates from Greece, where satires had begun originating slowly as time went by. The art of satire was challenged throughout the years to form the various forms of clowning we have today. A clown must have certain abilities or skills to master its comedy upon the audience. It is a profession that requires delicate detail, precise movements, and of course a reaction. The costume for every type of comedy is extremely different. Commedia Dell’Arte for example required masks for each of the characters, the masks obviated the use of face expression and communication, therefore making the characters more puppet like; relying more upon the use of voice and gesture. Masks were not only used in Commedia Dell’Arte but also in other forms of Greek and Roman dramas. Other forms of comedy usually consist of costumes focusing on the clown’s main faults and/or pertaining the clown’s own personality. Not only is costume used to make an impression on the audience when first sighting the clown; but also the make-up must be done right to enhance whether the clown is happy, sad, evil, or falls into another category of personality. The make-up also provides great detail, and in a way is a more modern format of the masks used in Greece and Rome during the 15th Century. When one thinks of clowning, the instant image in mind is the thought of clowns in a circus; performing acrobatic acts and leaving the crowd in awe. This is usually most typical for more ‘physical’ clowns, such as The Three Stooges. Though they do not look like the everyday circus clowns, they perform back flips, somersaults, and portray it all as clumsiness. A clown does not always need to impress an audience by acrobatics, but just by wit; though some audiences are more captivated by the appearance of a physical act. A physical act adds more stamina and energy to a scene, and can leave an audience laughing for hours. To make an audience laugh a voice is needed to speak and attract attention. Such attention can be provoked by the forms of an accent, exaggeration of the voice, or even silent mime. Though with a mime, more physical action is needed to involve the audience. Modern day clowns tend to stray more so towards no noise and a variety of sounds, exhorted from time to time.

Dance Critique Essay

Late last Saturday day night, on April 14,2012, I attended the very first dance concert at John Anthony Theater at Collin College Spring Creek Campus. This concert was performed by Collin Dance Ensemble, which is a vibrant company that performs innovative contemporary modern dance. Their goal is to produce dance works at the highest level of artistic excellence. The dance company attends and performs at the American College Dance Festival annually and has been selected for the Gala Performance at the regional festivals sevens times. At 7:30 pm, people started walking in to the theater, just a few minutes after, the audience seats filled with the crowed people who come to support the dancer, or maybe interested in dance performance, and mostly have â€Å"dance appreciation fever† like me. After the introduction of director, all the lights dimed down and the curtain slide up. The light focuses in the middle of the proscenium stage where there are group of seven dancers sat down in the middle of the stage ready to perform. They started it off with the piece called Friendships that was choreographer by the Chair of Dance Department and also a director of Collin Dance Ensemble, Tiffanee Arnold. Under the direction of Tiffanee Arnold, Collin College’s Dance Program has gained the reputation for excellence in dance education, choreography and performance. Music is Sinking Friendships by Jonsi, this piece was kind of bored to me as an unprofessional audience to really understand the concept of every part o f the story they tried to tell. Not very clear, but I can point out some of the movement of the dancer described the image of friendships such as holding hands and dance in circle as a group. And it was ballet so I’m not very interested. Outside topic, the theater was freezing cold. I try to concentrate to the performance to forget the coldness. The Time Between choreography by Reyna Mondragon is one of my favorite piece of the show. There were many of interesting parts, there were people ran across the stage back and forth while few others were illustrated the movement of time. The dance used running motion to create tick tick tick moves, it looked kind of cool to demonstrate the clock ticking. Through the  music by Clint DiFranco, Welcome to Lunar Industries, this piece is very modern. I love how to change the speed now and then during the performance. They just went freestyle in the climax of the song; there were a lot of running and walking movements, jumping, exciting and then they cut it out the slow motion dance with rhythm and powerful moves. People still ran across the stage, in my opinion they say that does not matter what’s going around you, time keeps running and life goes on. So far that night, one bored me and one got my attention to the show. Here comes the solo of Jake Harkey, the only male student in the group, performed Unseen Injuries by Tiffanee Arnold. This dance is in support of Collin College’s Center for Scholarly and Civic Engagement Book-In-Common: Soft Spots by Clint Van Winkle. And also it was inspired by several passages in the book, in particular: â€Å"But nobody talks about the mental wounds. It is the unseen injury that slips through the cracks, leads people to drinking, puts pressure on spouses, and causes healthy men to call the fire department for host symptoms. You are suppose to about-face and forward-march, forget about the war as soon as you get home, take 800 mg of Motrin and carry on like nothing ever happened. But how was I supposed to let go when I was reliving it every day?† (p.137; C. Van Winkle). One soldier, one person stood still in the middle of the stage. He was on the basic training clothes letting all the extensive madness out of his head. He raised the hands to try to reach out a reality of peace. Sometimes, he look back at what he had done as a soldier and all the images of war come back in his mind. The stress out anger movement was dynamic with the vocal sound. I can feel the pain through what he wanted to tell. He used wide range of space to show the falling and depression. He nailed the part wonderful as a college student. The one-foot stand come up to me as unbalance mind of a soldier in the war. Growing up in a country had a long history of fighting in war, I learn and see a lot about the soldier that come back from the war through real life and books. I can see in them not only the physical pain they had been through but also the spiritual scar that the war had impacted in them. I think that is why this piece Unseen Injuries gets my intention the most. The obsession will follow  them for the rest of their life. Narrative modern dance described the feeling of those soldier had been yearly in war. The performer was success to send out emotion of a soldier after war. It would seem sadly they are often overlooked impacting not only the injured but their friends, families and wider communities. Those with psychological trauma can go undetected and it can be years before medical treatment is sought. Tiffanee has a great choice on music of Message in a Bottle: Nancy’s Letter. Farewell Nancy by Ed Harcourt is very romantic and particular fit in the motif of this dance. I see a lot of dancing on ground level to create the sea scene. Soft and flexible are the word to describe their actions. The music inspired me to more focus on the dance. It represents the emotion of the main character want to see her lover so badly in distance relationship. And she also is a quite entertainer with piece Can’t Shake It. It got people excitement by their funky dance moves on those fluffy dresses. The audiences included myself were very enjoyable in this song. They showed that they couldn’t shake most part of their body from their trunk to head. Shame face and frustrated movements revealed to be ashamed part of their body couldn’t be shake. I think the dancer also enjoy themselves in such a piece. The performer are all college student so they were bit lack of perfection timing with each other and the steady movements which required in most ballet pieces. They were connected to the audience strongly in Scars, strong movements and ran toward downstage at the end. I would they were success to give out the message of each piece to me as the audience. Just a few was kind of bitter to figure out. I was born in 90s so ballet and jazz were not my type of entertaining dance. It is little bit far from my generation. But modern is more enjoyable to me. I like to move fast with rhythm especially hit all the beat of the music is way cooler. I don’t know any of Jazz moves in there cause I cannot tell. One thing I saw a lot that the modern and ballet, those dancers use many of motif manipulations such as incorporative with the turn and jump, repetition, levels (ground, middle, high jump),  rhythm was actually the part that I pay attention the most. Overall the concert was very great to me. Couple piece I did not understand what they try to say at all or I just did not be interested. Through all pieces by Tiffanee Arnold, I see that her choreography always tell a story along the dance. There is always something meaningful and deep down inside the performance that she wants the audience to see the piece and later on cautious thinking the background story.

UHHH.. RIGHT OR LEFT Professor Ramos Blog

UHHH.. RIGHT OR LEFT The arizona heat fills the car that carries my four friends James , Jasmine, Victor and myself all very hungry and lost. Now it was my time to prove to them that I Carlos the one that is very bad with directions can actually guide them to their first destination. Yet thats what I assumed would happen with my first go at using a map. Having previously learned how to use it, as what I thought I did I had full confidence that my new found skills could not only impress them but prove that I could actually lead a group. As we proceed down the desert road it was now my turn to give James who was driving, the first pieces of directions first a right then a left and so on. James however is the least patient in our group turns to me with slight tension in his voice Carlos are us sure about where we are going? With full confidence I say yes with no phone service to verify it he simply took my word and proceeded to drive. Although one thing they didnt know was that this was my first time using a map. So lets backtrack this story before everything would turn into a twist no literally. My dad who is the expert at camping trips is a 5’6 guy who also just like James has no patience when it comes to certain situations. When telling my dad about the trip he was so excited that I’ll be exploring and leading a group just as he used to do with my family when we were little kids. It started out with a simple talk about what to pack and soon came down to the question of so do you have a map or any sort or gps system. Being a millenial when I heard the word map I immediately in my head was like uhh†¦ yeah I have it on my phone pops were in the 20th century. After my inner talk my dad had brought to my attention that the places that I would be going would probably have no phone service. Soon after he pulls out a map that is folded about a million times I would have thought it was a failed origami project the size of a billboard. When I looked at it, it was very intimidating and brought about instant anxiety since not only will I be in a different state but that I would be having to lead my friends on our trip. My dad started to first list out the features of the map the compass, looking at which highway would connect to the next and so on. Also to mention that this was the day before my trip since Im pretty bad procrastinator he gave me what I had to know but with a lot of detail. We sat at the kitchen table for what seemed like forever as he instructed me and reassured that I would be perfectly fine and just to have confidence in myself. Later on that day I sat in my room packing all my goodies when I glanced over at that dreadful map and just like it felt like everything my dad had taught me suddenly disappear. Overthinking every situation possible I skied myself out and went back to his room to get another crash course on it. This time he seemed a little irritated since the lesson before seemed to slip my mind but my lovley mom backed me up. Yet again we sat down and he began to go back to the map but this time giving me the main things points that I needed to know. So now this leads us back to our story, once I gave James the next place to turn everyone in the car drew about an uneasy feeling that we were going the wrong way. We stopped in a small town that surprisingly had phone service to verify if   I was going the right way. Only to find out that the last 50 miles we had being going the wrong way. Frustrated everyone voiced their opinion in a small toyota corolla each voice overlapping the other. Although at the time I felt like I was defeated I still had an open mind that maybe I’ll be able to get the next one right, well thats if they can trust me. Eventually we made it to our destination and woke up to venture out to our first national park. Reminiscing about the night before laughing about how we all turned into monsters the past night we had high hopes that it would be worth it. We entered the park and the park ranger yet again they handed me that folded up map but this time it was the park map. I know it may not have been a super complex map but it still showed different routes to take the shuttle bus to get around different places on the mountain. I seen this as my golden opportunity to try to not only prove to myself and my friends that I can lead them and not get them killed this time. We all sat in a circle on a small patch of grass that looked from the outside like we were out to plot something with a map in the middle.   However I couldnt just jump in after getting them lost so I made slight opinions but they were merely laughed off. Jasmine suggested a trail and we begin our journey to hop from bus to but when we got off†¦. It wasnt our stop when looking at the map we had caught the wrong connecting bus. We all looked at each other as if this was a repeat of last night but we saw the silver lining since there was another trail nearby that was just as beautiful as the one we expected to arrive at. At last our trail was done and now we were all very sweaty hot and ready to pack up and head back to the campsite. Mumbled words under heavy breathing are the layers of voices that asked which bus do we take? With the very little energy still in me I pushed my voice through my gasping lungs and said Oh I know! With really no energy to argue if we would get lost they simply followed me on the first bus. It wasnt till the AC of the bus had cooled me off that it had all settled in. I pulled out the map and begin to retrace the important lessons my dad had taught me but at times the anxiety of messing up was lingering in the back of my head. We had finally arrived to the place were we had taken the wrong bus but by now everyone was cooled off but very tired so I built up the courage to get there since this was the final leg of the journey. For one last time I opened my bag to reveal the wrinkled map and unfolded every part to reveal the way back. I then began to retrace where we had made our mistake and guided us to the connecting bus that took us back to the parking lot. Once I stepped foot off the bus it felt as though I was lost at sea and was finally seeing the shore just a few miles away. In the car they all begin to mess with me and say that we made it alive but also gave props on the fact I was able to get everyone back. This trip taught me to not only learn how to begin to read a map but also to have confidence in anything that I do. We tend to doubt ourselves and never fully commit to trying something even if it means making mistakes. However it all paid off in the long run like exploring new trails that we had never seen before to the everlasting stories like the one I just told. This also painted new memories of bounding with my dad and building a stronger bond with him and my friends.To this day Im still learning how to read it and still getting lost but at least this time for now I have my gps and the confidence to take on any adventure.

Make the Most of Your Tactile Learning Style

Make the Most of Your Tactile Learning Style According to some educational theorists, there are as many as nine different types of intelligence and multiple styles of learning. Tactile or kinesthetic learners are those who learn through experiencing and doing things. How Tactile Learners Learn Tactile learners like to experience the world and act out events. To remember a phone number, tactile learners may remember the pattern of their fingers as they  press the numbers on a phone or keypad. Tactile learners can remember complicated directions once theyve acted them out. Look over these traits to see if they sound familiar to you. You may be a tactile learner if you are someone who: Is good at sportsCan’t sit still for longIs not great at spellingDoes not have great handwritingLikes science labStudies with loud music onLikes adventure books, moviesLikes role-playingTakes breaks when studyingBuilds modelsIs involved in martial arts or danceIs fidgety during lectures Challenges for Tactile Learners Because tactile learners learn best through movement, they may become bored more quickly than other students while listening to a class lecture. They may also find it difficult to focus on long lectures, write extended essays, or read for extended periods of time. Study Tips for Tactile Learners An active study is good for every student. But it is especially important for the tactile learner to use active study strategies when preparing for a school exam. Tactile learners need to be actively involved as they receive and process new information. Kinesthetic learners can benefit from: Studying in short blocks of timeRole-playingTaking lab classesTaking field trips or visiting museumsStudying with othersUsing memory gamesUsing flashcards to memorizeUsing a smart pen for taking notes. A smartpen records audio content that takes place while the student is taking notes. That means that students can go back to review class notes and listen to any lecture that took place as the student recorded notes.Acting out the topics, stories, and subjects they study. For example, activities like reacting to the past enable students to immerse themselves in the topics and experience subjects they study.   Tactile learners may choose to use the Journey Method for memorizing new information (mentally placing concepts in a location). Learning games and group activities are good tactics for the tactile learner. The more active this student can be during study time, the more information that study is likely to retain. When preparing for an exam of any type, the tactile learner should practice writing a test essay (make up your own essay questions). Write the first essay using the textbook as a guide, then practice the essay several times in preparation for test day. Opportunities for Tactile Learners Certain types of classes are likely to appeal to tactile learners. For example, tactile learners will thrive in the sciences that include a lab experience. They are also likely to do well in classes that combine hands-on and conceptual learning such as: Culinary artsHome economicsEarly childhood developmentTheater or other performing artsVisual arts (sculpture, for example)Engineering If you are a tactile learner in a high school or college setting, consider choosing electives or a major that makes the most of your strengths.

15 Positions and Their Variations

15 Positions and Their Variations 15 Positions and Their Variations 15 Positions and Their Variations By Mark Nichol Position, as a verb meaning â€Å"set† or â€Å"place† and as a noun referring to the attitude or location in which something is set or placed, is derived from the Latin verb ponere, as are a number of terms using that word as a base to form new meanings revealed more or less transparently by their prefixes. A list of these verbs and nouns, as well as a few related adjectives, plus simple definitions and their literal meanings for each word, are included here. appose: put near (â€Å"set near†) apposite: appropriate, well placed (â€Å"set near†) apposition: noun or noun phrases with the same meaning set adjacent to each other, or that relationship; also, proximity, or the deposition of layers (â€Å"something set near†) compose: create (â€Å"set with†) composer: a creator (â€Å"one who sets with†) composite: made of different parts (â€Å"set with†) composition: a creation (â€Å"something set with†) decompose: disintegrate (â€Å"removing something from being set with†) decomposition: disintegration (â€Å"something removed from being set with†) depose and deposit: put down (â€Å"remove from being set†) deposit and deposition: something put down (â€Å"something removed from being set†) dispose: put away (â€Å"set away†) disposal and disposition: the act of putting something away; disposition also refers to an attitude, mood, or tendency (â€Å"something set away†) expose: show (â€Å"set out†) exposition: something shown (â€Å"something set out†) expository: shown (set out†) impose: place pressure on someone (â€Å"set on†) imposition: pressure placed on someone (â€Å"something set on†) interpose: interrupt or place between (â€Å"set between†) interposition: interruption or placement between (â€Å"something set between†) juxtapose: place together for comparison (â€Å"set beside†) juxtaposition: placement together for comparison (â€Å"something set beside†) oppose: disagree (â€Å"set against†) opposite: against (â€Å"set against†) opposition: disagreement (â€Å"something set against†) presuppose: assume or require something is true, exists, or will happen (â€Å"set on before†) presupposition: an assumption that something is true, exists, or will happen (â€Å"something set on before†) propose and proposition: suggest (â€Å"set forth†) proposal and proposition: a suggestion (â€Å"something set forth†) superimpose: place on top of something else (â€Å"set over†) superimposition: something placed on top of something else (â€Å"something set over†) superpose: same as superimpose, but with an additional sense of placing geometric figures congruently atop each other suppose: assume (â€Å"set under†) supposition: assumption (â€Å"something set under†) suppository: medicine placed in the rectum or vagina (â€Å"something set under†) transpose: move away (â€Å"set across†) transposition: movement away (â€Å"something set across†) Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:60 Synonyms for â€Å"Walk†Does "Mr" Take a Period?How to Treat Names of Groups and Organizations

Impact of Secondary use of Data Essay Example | Topics and Well Written Essays - 3000 words

Impact of Secondary use of Data - Essay Example In this scenario, secondary data is data that has already been collected by someone else for a different purpose and we want to use it. Some of the common examples of data collection could be: data presented by an organization for its business marketing, gathered by a hospitality firm on its guests by using its guest history system, annual business reports or Government statistics and figures (Thames Valley University, 2010). On the other hand data can be used in different scenarios such as: someone can simply present the original data in its unchanged format. In this scenario, probably this data will be used in the introduction or literature review as support or proof for their argument. A person can also make use of this data in a different way if this data is utilized (for analysis or interpretation) for a wide variety of purposes than the original then the most likely place would be in the ‘analysis of findings’ part of a research report or thesis. For instance, a research work carried out on suicide issue can comprise the official suicide data of different countries or regions (which was collected by government or their equivalent) and evaluate this data to determine if they could categorize variables that would indicate that some people are more likely to commit suicide as compared to others (Thames Valley University, 2010). However, there are numerous issues involved with the secondary usage of data. This paper will discuss the secondary uses of data, some of its advantages and disadvantages. In the end, this paper will discuss issues with secondary usage of data and laws to deal with these issues. Secondary Use of Data: An Overview No doubt secondary research can be considered as the most extensively used technique for collecting data as this process of data collection engages retrieving information that is previously collected from either the inventor or a distributor of primary research. In addition, secondary data comprises the information and data collected from third-party sources for instance a business website, sales and accounting records, marketing research reports and magazine articles. Moreover, it can also comprise any already collected information utilized by the vendor from any external or internal source (BlogSpot, 2008; Thames Valley University, 2010). Advantages of Secondary Use of Data In fact, there are a lot of benefits of making use of the s econdary data or research. First of the most important advantages of using secondary data is that it is relatively easy get access to a wide variety of sources of secondary data. Some time ago secondary data collection required business marketers or sales management to spend a lot of time in libraries, or wait for reports to be received via mail. On the other hand, at the present there exist a number of modern technologies for data collection for instance with the availability of the Internet and online access to a lot of digital resources, the access to the secondary data and information has become very simple. In fact, the Internet has become a convenient and usually standardized tool for all sources of secondary research. In addition, by making use of the secondary data researchers can be able to get access to important data and information for small or in many cases absolutely no cost to acquire. For that reason, this secondary data is much more affordable and less expensive as compared to other methods of data collection where researchers perform the research themselves. Additionally, the use of secondary data allows researchers to make clear the research problem. In many cases, secondary data is utilized before primary

I would like the picture Essay Example | Topics and Well Written Essays - 1000 words

I would like the picture - Essay Example Two small grey outlines on the bottom left look like people, and this gives an impression of the huge scale of the buildings. There is enough detail to work out the windows, the outline of the buildings, and the human figures, but beyond that the picture has more of an abstract look than a representational one. The rows of windows, for example, are just smudges, and there are very rough brush strokes indicating the contours of the objects in the picture. Outlines such as the left side of the building on the right are not exactly straight, and this gives the picture a fluid and dynamic look. A striking feature of this picture is the way that all the tones are soft and the dominant color is a pale pink. Yellow and blue tones, such as those on the roof portions of the two buildings in the center and right, complement the pink, and they rise out quite well from the background as if to point to the pale pink sky. There is, however, no stark color contrast. Even the grey dark grey tones are muted, so that there is a sense of unity and calm despite the busy urban subject matter. Audrey Ushenko’s painting of a restaurant scene presents a multitude of details which are difficult to capture all at once. There are strong dividing lines between different areas of the painting and this creates an impression of multiple smaller pictures arranged together into a composite larger scene. The bottom half of the painting is dominated by crowds of human figures. They are posed in groups, as if talking to each other, and this creates a confusion of connections, forcing the viewer to look closely at the faces in order to work out what is going on. The use of perspective and scale is very interesting in this picture. The bottom left corner is the largest, and appears to represent an upper tier of the restaurant. The bottom right of the painting is in a smaller scale, suggesting that this may be a lower level of the restaurant. This means that the brown dividers can be

Digestive system Lab Report Example | Topics and Well Written Essays - 500 words

Digestive system - Lab Report Example inactive form to active form: for instance pepsinogen (inactive form) to pepsin (active form); mucus helps to protect the stomach walls from corrosive effect of HCL. 3. Enzyme lactase helps in breakdown of lactose to simple sugars galactose and glucose; it does this by a process called hydrolysation whereby a molecule of water is released. Whole milk contains lactose this was broken down by enzyme lactase to galactose and glucose which led to increase of glucose concentration with time as more glucose was being released. Lactose-free milk stayed the same because it lacked lactose and lactase enzyme digests lactose only. 4. The pancreas is an organ that secretes pancreatic juice, a major digestive secretion. Alkaline pancreatic secretions help in neutralization of the acid chyme (food) from the stomach to a neutral or slightly alkaline pH; this is important because most pancreatic enzymes work best at slightly alkaline or neutral PH, excess acidic PH can also damage duodenal mucosa and cause ulcers. Pancreatic juice also contains enzymes, namely trypsin and chymotrypsin which digest proteins, lipase digests lipids to 3 fatty acids and glycerol and amylase for digestion of carbohydrates. 5. Gall bladder has three functions that are storage, concentration, and secretion of bile. Bile salts are important for emulsification of fats: the fats are broken into small droplets, and this increases surface area for more lipases to breakdown the fats to easily absorbable forms. Bile salts are alkaline; they neutralize the HCl in the chyme as it moves to the duodenum. Liver is associated with gall bladder function because it produces bile juice. 6. Chemical digestion and nutrient absorption in small intestines are dependent on each other digestive enzymes, and bile break food substances to absorbable materials which are absorbed into the blood systems through the walls of small intestines by either of these 3 processes - active transport, osmosis and diffusion, and in all

Dutch Style of Painting in the 17th Century Assignment

Dutch Style of Painting in the 17th Century - Assignment Example After the 1640s, many of the houses’ interiors contained scenes of daily life activities with some pictures and maps along the doorways. One of the paintings by Hedrick Sorgh in Rotterdam had a figure of a mother who devoted her time for her children (Hollander 2). In some scenes such as the courtship, paintings consisted of men and women drinking or playing music. Other paintings were biblical and mythological scenes on walls addressing various issues and narrating stories. Dutch paintings can say a lot just in a small setting through the conceptualization of the images. The texts and pictures were a form of entertainment and vehicles for persuasion and challenge in the 17th century. The secondary pictures in Dutch paintings were for commentaries and pictorial and not verbal representing the painters’ thoughts. The paintings provided the aspect of rhetoric and a chance to consider many sides of the issues both simple and complex. The splitting of images into several pa rts is a fundamental feature of the Western image making as it occurs in the medieval pictorial systems. The separation of the pictures provided a wider theme for the picture or narrative. In March 2015, Dutch Paintings of the Seventeenth Century earned the prestigious George Wittenborn Memorial Book Award from the Art Libraries Society of North America (ARLIS/NA) for excellence in art publishing. â€Å"The selection of Dutch Paintings of the Seventeenth Century acknowledges a transformational achievement in art historical publishing,†.

Marketing Assignment Example | Topics and Well Written Essays - 250 words - 3

Marketing - Assignment Example â€Å"Since Havaianas emerged from its reinvention strategy in 1994, sales have been growing by a steady 8 percent each year. In 2008 the company sold 184 million pairs of its now famous rubber sandal, 25 million of which were sold outside Brazil. Inside Brazil, the company has achieved the amazing brand penetration rate of 850 pairs sold per 1000 inhabitants† (Havaianas, n.d.). The efforts of the company to build the strong image of the brand internationally took them number years to attain. Thus, the emerging imitations of Havaianas somehow thwart the good image of the brand. The deception that these imitations are giving to the consumers makes them believe that they will get the same value of the product in buying an authentic one. This act does not only transpire stealing the brands name and image but it also harms the consumers as they are not getting the value for their money spent. Also, Havaianas might have an image of delivering poor product because of the existing fa ke brands. This ethical dilemma in Havaianas marketing is something that will not be easily controlled as there are a lot of players in the industry today that had been imitating products one after the other.

London, New York and Tokyo as Global Cities Research Paper

London, New York and Tokyo as Global Cities - Research Paper Example Founded by the Romans, London stands on River Thames and has acted as a key settlement spot for almost two millennia (Beaverstock 114). New York City, located in New York State in the Northeastern expanse of the United States, is the state’s and nation’s most populous city. Courtesy of New York City, New York State is presently the United States’ largest and busiest immigration gateway. Japan’s capital city, Tokyo, is also the world’s largest metropolitan area and among Japan’s 47 prefectures. Ancient history suggests that Tokyo was a fishing village in the 15th century, but has evolved through being a cultural, religious and military stronghold to its present economic giant status. Presently, Tokyo is home to the Imperial Family of Japan and the government’s headquarters. In the context of â€Å"global cities†, London, New York and Tokyo lead the world, and are classified as Alpha++ cities. Alpha++ cities are the most globally integrated cities with other. In this perspective, global cities form critical nodes in the worldwide economic framework (U.S. Census Bureau 96). The first part of this paper will provide a brief historical background and overall economic profile of the three cities. Then, it will examine the details of size and diversity of the population and labor migration of the three cities. ... In 1176, a new stone bridge replaced the wooden one built by the Romans. During the reign of Edward III, London became a true capital (Beaverstock 121). Economic Profile Presently, finance remains the largest industry in London, with financial exports contributing largely to the balance payments of the United Kingdom. This makes it a key economic and commercial center for multiple interests on the international business platform, ranking fifth among the world’s largest city economies. In 2012, its Gross Domestic Product (GDP) was estimated at slightly above $ 731 billion. Per capita GDP for the same year was at $51,798 (U.S. Census Bureau 78). With its economic profile, London as a city has been generating about 20 percent of the entire United Kingdom’s GDP for the past decade, while the metropolitan area on its own generates 30 percent. As per statistics at the beginning of 2013, with over 841,000 businesses in the private sector, London had the highest number business es than all other regions and countries in the United Kingdom. Out of the private sector businesses, 30 percent are collectively in the professional, technical, scientific and construction industries, forming a significant part of the small and medium enterprises (SMEs). The major business districts are, in ascending order, Lambeth & Southwark, Canary Wharf, Camden & Islington, Westminster and The City, where economic activities range from accountancy to legal, real estate, architecture and government operations (Scheltema & Westerhuijs 69). Size and Diversity of the Population Between the 16th and 19th centuries, London’s population grew from 50,000 to 900,000 in spite of unhealthy

Dutch Style of Painting in the 17th Century Assignment

Dutch Style of Painting in the 17th Century - Assignment Example After the 1640s, many of the houses’ interiors contained scenes of daily life activities with some pictures and maps along the doorways. One of the paintings by Hedrick Sorgh in Rotterdam had a figure of a mother who devoted her time for her children (Hollander 2). In some scenes such as the courtship, paintings consisted of men and women drinking or playing music. Other paintings were biblical and mythological scenes on walls addressing various issues and narrating stories. Dutch paintings can say a lot just in a small setting through the conceptualization of the images. The texts and pictures were a form of entertainment and vehicles for persuasion and challenge in the 17th century. The secondary pictures in Dutch paintings were for commentaries and pictorial and not verbal representing the painters’ thoughts. The paintings provided the aspect of rhetoric and a chance to consider many sides of the issues both simple and complex. The splitting of images into several pa rts is a fundamental feature of the Western image making as it occurs in the medieval pictorial systems. The separation of the pictures provided a wider theme for the picture or narrative. In March 2015, Dutch Paintings of the Seventeenth Century earned the prestigious George Wittenborn Memorial Book Award from the Art Libraries Society of North America (ARLIS/NA) for excellence in art publishing. â€Å"The selection of Dutch Paintings of the Seventeenth Century acknowledges a transformational achievement in art historical publishing,†.

London, New York and Tokyo as Global Cities Research Paper

London, New York and Tokyo as Global Cities - Research Paper Example Founded by the Romans, London stands on River Thames and has acted as a key settlement spot for almost two millennia (Beaverstock 114). New York City, located in New York State in the Northeastern expanse of the United States, is the state’s and nation’s most populous city. Courtesy of New York City, New York State is presently the United States’ largest and busiest immigration gateway. Japan’s capital city, Tokyo, is also the world’s largest metropolitan area and among Japan’s 47 prefectures. Ancient history suggests that Tokyo was a fishing village in the 15th century, but has evolved through being a cultural, religious and military stronghold to its present economic giant status. Presently, Tokyo is home to the Imperial Family of Japan and the government’s headquarters. In the context of â€Å"global cities†, London, New York and Tokyo lead the world, and are classified as Alpha++ cities. Alpha++ cities are the most globally integrated cities with other. In this perspective, global cities form critical nodes in the worldwide economic framework (U.S. Census Bureau 96). The first part of this paper will provide a brief historical background and overall economic profile of the three cities. Then, it will examine the details of size and diversity of the population and labor migration of the three cities. ... In 1176, a new stone bridge replaced the wooden one built by the Romans. During the reign of Edward III, London became a true capital (Beaverstock 121). Economic Profile Presently, finance remains the largest industry in London, with financial exports contributing largely to the balance payments of the United Kingdom. This makes it a key economic and commercial center for multiple interests on the international business platform, ranking fifth among the world’s largest city economies. In 2012, its Gross Domestic Product (GDP) was estimated at slightly above $ 731 billion. Per capita GDP for the same year was at $51,798 (U.S. Census Bureau 78). With its economic profile, London as a city has been generating about 20 percent of the entire United Kingdom’s GDP for the past decade, while the metropolitan area on its own generates 30 percent. As per statistics at the beginning of 2013, with over 841,000 businesses in the private sector, London had the highest number business es than all other regions and countries in the United Kingdom. Out of the private sector businesses, 30 percent are collectively in the professional, technical, scientific and construction industries, forming a significant part of the small and medium enterprises (SMEs). The major business districts are, in ascending order, Lambeth & Southwark, Canary Wharf, Camden & Islington, Westminster and The City, where economic activities range from accountancy to legal, real estate, architecture and government operations (Scheltema & Westerhuijs 69). Size and Diversity of the Population Between the 16th and 19th centuries, London’s population grew from 50,000 to 900,000 in spite of unhealthy

Body Ritual Among the Nacirema Essay Example for Free

Body Ritual Among the Nacirema Essay Sandra Bullard November 27, 2011 Body Ritual Among the Nacirema Dr. Chan Body Ritual Among the Nacirema The Nacirema are a North American group living in the territory between the Canadian Cree, the Yaqui and Tarahumare of Mexico and the Carib and Arawak of the Antilles. According to the Nacirema mythology, their nation was originated by a culture hero, Notgnihsaw, who otherwise known for two great fears of strength- the throwing of a piece of wampum across the river Pa-To-Mac and the choppin down of a cherry tree in which the Spirit of Truth resided. The focus of the Nacirema culture is the activity of the human body, appearance and the health of which loom as a dominant concern in the culture of the people. The belief underlying the whole system appears to be that the human body is ugly and that its natural tendency is to debility and disease. In the hierarchy of magical practitioners in the Nacirema culture, second in the lineup are the holy-mouth-men. The Nacirema have a pathological horror of and fascination with the mouth, the condition of which is believed dto have a supernatural influence on all social relationships. If it weren’t for the rituals of the mouth, they believe that their teeth would fall out, their gums bleed, their jaws shrink, their friends desert them, and their lovers would reject them. People seek out a holy-mouth-man once or twice a year. Holy-mouth-men have an impressive set of paraphernalia, consisting of a variety of augers, awls, probes, and prods. The use of these objects are for the exorcism of the evils of the mouth. The holy-mouth-man opens the client’s mouth and, using the above tools, enlarges any holes which decay may have created in the teeth. If there are no naturally occurring holes in the teeth, large sections of one or more teeth are gouged out so that the supernatural substance can be applied. In the client’s view, the purpose of these ministrations is to arrest decay and to draw friends. The natives return to the holy-mouth-men year after year in order to keep sacred and traditional character of the rite. The medicine-men of the Nacirema community have an imposing temple, also called latipso. The latipso is a very elaborate ceremony that is required to treat very sick patients only. These ceremonies are so harsh that it is amazing that the sick natives who enter the temple ever recover. When the supplicant first enters the temple, they are first stripped of all off his or her clothes. In every-day life the Nacirema avoid exposure of his body and its natural functions. Once in the latipso, the body secrecy is lost and the man finds himself naked and assisted by a vestal maiden in which he then performs his natural functions into a secret vessel. These procedures are necessitated by the fact that the excreta are used by a diviner to ascertain the course and nature of the client’s sickness. Female clients who enter the lapitso, find their naked bodies are subjected to the scrutiny, manipulation and prodding of the medicine men. One way that these people address wealth is with shrines. Every household has one or more shrines. The most powerful individuals in society have several shrines in their houses. The shrine rooms of the more wealthy are walled with stone. Poorer families imitate the rich by applying pottery plaques to their shrine walls. Another way I think wealth is defined in their community is the gifts that are given to guardians of temples. The lapitso’s guardian for example, will not admit a client if he cannot give a rich gift to the custodian. And once a client is admitted, they must be able to give the custodian another rich gift before being let out. Cultural relativism is demonstrated by Horace Miner and his capability of understanding and gaining trust of the individual’s culture. The individuals of the Nacirema community opened up to Miner and let him see their sacred and traditional rituals. It was his willingness and openness that let the Nacirema community to trust him. It’s hard for me not to display ethnocentrism towards their community and rituals because it’s completely different from what I have learned and grown up with. None of their rituals that they perform make any sense to me. For example, the women putting their heads in the oven and letting them bake for an hour is hard for me to understand and conceptualize. So, it’s hard for me to say that I think that they’re strange, because that’s their culture and that’s the only think they have ever known. When I put it in perspective and think about their opinions on our culture, they wouldn’t know why we do the things we do within our community. It is very interesting to read about people who once lived in North America and maybe still do live in North America that perform these types of ritual.

Effects of Prevalence Expectation on Visual Search Behaviour

Effects of Prevalence Expectation on Visual Search Behaviour Page | 1 Introduction The objective of this research is to investigate the effects of prevalence expectation on visual search behaviour and cognitive function in radio-diagnosis of the adult chest radiograph and its impact upon medical expert witness testimony in malpractice litigation. Research into radiological error has consistently demonstrated disparity in radiological performance. Most studies of radiology error report significant rates of intra and inter observer variability. The pertinent question is why do radiologists make mistakes? â€Å"Conventionally, radiologists produce diagnoses on the basis of a combination of their training, experience, and individual judgment. Radiologists perceive and recognise image patterns and associate or infer a diagnosis consistent with those patterns.† [1] Accurate results depend upon the radiologist’s ability to recognise a lesion, ignore irrelevant details, and retrieve pertinent memories in order to accurately interpret an image. The radiologists primary task is to accurately identify a range of anatomical structures and pathological findings on medical images. The diagnostic process in radiology is not well understood. Basically, radiologists perceive and recognise image patterns and then associate or infer a diagnosis consistent with such patterns. Appearances on a radiograph are silhouettes of normal and abnormal anatomy. Each shadow represents a projection of layers of detail on a two dimensional surface from a three-dimensional object. The successful detect ion of the target and the time required to seek it out depends upon a number of external factors Much information needs to be processed by the radiologist during the interpretation of such shadows. The disease pattern, The clinical and demographic information relating to the patient The differential diagnoses pertaining to such a pattern. The experience of the radiologist A general aspect of everyday life is looking for a particular target amongst an assortment of other (distracting) items. Visual Search is one task that is performed routinely from radiological diagnosis to finding a definitive research text in a library. Visual search is an essential element in the cognitive process and is the interaction between the visual system, its target and the reader’s subsequent decision. Each experiment was conducted in a controlled laboratory environment, but were designed to simulate, as near as possible, the clinical arena. Expectation is explored by manipulating the information given to radiologists between general clinical information and very specific clinical information, thereby encouraging each radiologist to formulate an individual expectation of abnormal prevalence in the images presented to them. We then measured any subsequent change in behaviour as the subjects’ biases shifted. It was hypothesised thata radiologist would vary their decisions at the cost of more or less false alarms. This is termed criterion shift. The amount by which a radiologist considers false alarms to achieve a higher rate of detection is termed the bias. Bias represents an approach to lessen the consequences of a missed target. What is visual search? In a visual search task, subjects look for a target item among a number of distracting items. [1] After breaking down an image into its distinct components, the visual system directs attention to unusual areas for further analysis. This act of looking for and selecting an anomalous feature on a radiographic image is termed visual search, and is the task performed by radiologists daily. At a very basic level, there are generally considered two types of visual search termed pre-attentive and attentive. A great deal of research has been conducted regarding the differences between these two types of visual search and the factors that affect performance during each [2, 3]. Pre-attentive search has been given a number of labels including efficient search, parallel search, easy or effortless search [1] and automatic detection [4]. In this type of search, the targets are anticipated to contain features which are processed pre-attentively [5], basically drawing attention to themselves. In this type of search, the target appears immediately to the observer, requiring little search effort. For example when searching for the letter X on a page of letter Os or for a red target in a mass of blue targets. Attentive search also referred to as inefficient search [1] serial search [4] and controlled search [2] refers to a complicated search in which attention must be given to targets much less obvious. These components are influenced respectively by the characteristics of the environment (e.g., saliency of targets and distracters) and learned search strategies. The distinction between these two types of search is consistent with the view that search is driven by both bottom up and top down processes [6] wherein bottom up processes drive attention due to salient features in an environment or target features and top down processes drive attention through the function of search strategies such as the direction of attention to locations of high priority. Experienced radiologists develop a mental global impression of a standard radiograph [7, 8] sometimes called a target template [9] and in some instances use pre-attentive search as the abnormality is almost instantaneously visible. Conversel y they may use the second approach in more difficult cases. Recognising how these factors influence target detection helps to understand real-world search tasks and cognitive psychology. Together, the results can help to show how different influences affect visual search in the performance of real-life search tasks as in medical radiology, and airport baggage security. Fiore et al [10]) define threat detection in an airport screening task as the ability to rapidly recognise targets in the environment and interpret the meaning and importance of these cues. Nodine et al [11] break the radiological interpretation task down into three elements, describing the task as consisting of a search for, the recognition of an abnormality and the decision made regarding the abnormality. Many occupations depend on the speedy and effective execution of a visual search. Surf life savers in Australia are trained to search the ocean for rips, sharks and for swimmers in difficulty. Diamond cutters need to be able to evaluate the cutting potential of a rough diamond and need to be able to look at a diamond crystal and determine whether it will yield a large enough gemstone to make a profit.The quality and price will vary greatly based on the cut quality [12]. Airport baggage security screeners are trained using Threat Image Projection (TIP) technology to detect potential threat items within an X-ray image that may contain harmless clutter. There are various features which might hamper a successful visual search, including item superimposition, different viewpoints, rotation of the item and general image complexity. A number of other demands may also influence search, including psychosocial pressure (a busy airport might provoke a too rapid search), expectation (a threat it em is a rare occurrence), boredom and the number of different targets added to the list of dangerous or suspicious items. Errors in these areas are potentially life-threatening, expensive or both. In the medical arena, diagnosis in cytology and radiology are two areas that are dependent upon visual search. Clinical understanding and proficiency in visual pattern recognition serve as the basis for diagnosis by radiologists and pathologists [13]. Error in Radiology Imaging departments must offer a top quality radiological service with as little risk to the patient as is possible. It is therefore incumbent upon radiology department to address any problematic areas and try to reduce the causes of error. The accuracy of the radiological report is one element of the patient’s care. In radio-diagnosis, errors are either of perception or cognition [14]. Perceptual errors occur when targets (tumours, infection) are not visualised. A cognitive error occurs when an abnormality is seen but the radiologist draws the wrong conclusions due to unsound diagnostic reasoning. Diagnostic errors are classified as either false positive (FP) or false negative (FN). A false positive decision is due to the interpretation of a presumed target as pathological when it is in fact normal. A false-negative is an abnormality that is present but is not perceived. FN errors errors are five times more likely than FP errors [15], whilst perceptual errors are four times more frequent than decision making errors [14]. Radio-diagnosis not an exact science. Approximately 4% of Radiological interpretations contain errors, fortunately, most of these errors are clinically insignificant, or if serious errors are found, they are promptly corrected causing no harm to patients [16]. Identifying and locating items can be challenging especially when one is uncertain of where, or even what, to look for. Difficulties are more likely to occur when observers must locate the target’s position rather than simply detect the target’s presence [17]. Numerous studies have been conducted to understand error in radio-diagnosis. This issue has been recognised for a number of years. In the 1940s, Garland [18] found that 10-20% of chest radiographs of patients with suspected tuberculosis (TB) were read differently by different observers and a study by Quekel et al [19] observed that 19% of lung cancers presenting as a nodule on chest radiographs were missed. Another study [20] identified major diagnostic variation between three experienced radiologists interpreting medical images of patients in an emergency department. In this study the level of diagnostic agreement between the radiologists varied according to the anatomical area examined. Levels of agreement were abdomen (51%), chest (61%) and musculoskeletal (74%). There are a number of influences that affect the perception and diagnosis of chest lesions. Of these influences, prevalence expectation has had very little study. Target prevalence and prevalence expectation Prevalence expectation or bias occurs when expectations about an outcome influences a subject’s behaviour. In radiology this can be a factor during diagnosis. For statistical reasons, laboratory studies of visual search in typically include targets on 50% of all trials and participants often recognise that any given trial has an equal chance of having a target or not. However, real-life searches are seldom so balanced. In airport security, baggage screeners view numerous x-ray images of suitcases, but the incidence of a dangerous item happens infrequently. Consequently, one issue in visual search is exploring how a difference in target prevalence modifies searcher expectation and subsequent detection performance. This issue has been raised in multiple domains, including vigilance studies, radio-diagnostic perception, and cognitive psychology. In routine radiological examinations, the occurrence of abnormalities is generally low. This frequency fluctuates depending on the demographics of the population and the anatomical area being examined. However, in all cases, a mis-diagnosis might result in serious consequences. Research within radiology has therefore attempted to show whether low target prevalence is responsible for diagnostic error. Whilst a number of studies, within the medical and non-medical domains, have investigated whether the number of targets present (prevalence) can affect performance. [21, 22, 23, 24], there has been almost no research undertaken regarding the effect of prevalence expectation.

The Divine Comedy Essays -- essays research papers

During the Middle Ages, the church was a powerful institution. It had its own government, courts, system of taxation, and laws. To live a good Christian life guaranteed access to heaven in the afterlife, and a life of sin was to be sentenced to hell. Dante Alighieri was an Italian poet, who had an admirable depth of spiritual vision and was known for his intelligence (Encarta, 1). Between the years of 1308 and 1321, Dante wrote the epic poem, 'The Divine Comedy,'; which described a journey through the afterlife. It takes place during the three days of Good Friday, when Jesus died, and on Easter Sunday when he rose body and soul to heaven. It is a moral comedy, and was written to make readers evaluate their own morals. The journey was to show readers what could happen if they live a sinful life, or if they live a godlike life. 'In the middle of the journey of our life I came to my senses in a dark forest, for I had lost the straight path. Ah! How hard a thing it is to tell what this wild and rough and difficult wood was, which in thought renews my fear! (Alighieri, 1)'; This passage tells us that Dante is lost in the middle of the woods, and he is in the middle of his life. The reason he gives for being lost is that he had become inattentive and was not paying attention to where he was going. This symbolizes how he has lost his quest for salvation. His laziness, a sin, caused him to stray from the road of salvation. He can't go back the way he came because that is the way o...

The Lives of the Inuit Essay -- World Civilization

When you mention Alaska and the Arctic Circle, one envisions igloos, dog sleds, and invariably, Eskimos. However, little do most know, that what most refer to as Eskimos is actually a generalization representing three distinct groups. In order to understand the societies that live in this region and acknowledge their cultural differences we must explore the different groups that inhabit this region of which there are two: the Inuit, and the Yupik. For the purposes of this discussion we will focus on the lives of the Inuit. The Inuit are a group of people often mischaracterized as Eskimos. They lived in the area of central and northeastern Canada and Greenland. There has been much discussion of the orignination of this group of people but the most recognized theory is that they crossed from northern Asia across thin bridge of land over the Bering Strait sometime around 6000-2000 BC. Many people mistakenly think that the Inuit and Native Americans are one in the same. It seems that the Inuit most likely came from Asia more likely than the Native Americans. Although both probably came to the Americas through the Bering Strait. Biological, cultural and dialect differences show the different origin. Much of this theory is supported due to the close resemblance of the Inuit to the Mongoloid races of Eastern Asia. Because of the harsh land and climate of the Arctic, this area was probably one of the last regions to be inhabite d making the Inuit on of the earth’s younger cultures. A large portion of the Inuit culture was developed based upon the need to survive. Migratory societies such as the Inuit were driven by the need for food to feed its members, by the availability of trade to secure resources not normally available ... ...ith many fluctuations in prices due to fashion trends, especially in Europe. With the growth of the animal rights movement in the 1960s, fur prices decreased to the point that the industry was only barely sustainable. At the same time, the HBC trading posts had morphed into retail stores, and were doing a different kind of business across the North. They exist today as the Northern Store in the communities, a sort of grocery plus department store. Works Cited Jones, J. Sidney. (2012). Inuit, . Retrieved March 11, 2012, from http://www.everyculture.com The Inuit Culture. (2009). Retrieved March 10, 2012, from http://www.mythicjourneys.org Frederic V. Grunfeld (Ed.), Oker: Spiele der Welt II. (in German) Fischer, Frankfurt/M 1984. ISBN 3-596-23075-6 Pulaarvik Friendship Kablu Centre (2007). Retrieved March 7,2012, from http://www.pulaarvik.ca

French Revolution and Napoleonic Era Worksheet Essay

1. Essay Explain, in 1,050 to 1,400 words, how the following ideas and ideals influenced the events and motivated the participants in the French Revolution: Liberty Equality Brotherhood Hubris Fiscal irresponsibility Democracy Technology 2. Napoleonic Timeline For each date and location, identify the significant event that occurred and write a single-sentence description of the event. August 15, 1769 Napoleon Bonaparte was born. Ajaccio, Corsica July 4, 1776 The Declaration of Independence was approved by the Second Continental Congress meeting in the Pennsylvania State House. Philadelphia, Pennsylvania July 14, 1789 The citizens of Paris ignited the French Revolution by storming the Bastille prison and released seven prisoners. Paris September 21, 1792 The monarchy was abolished France January 21,1793 King Louis XVI was executed. Paris August 22, 1795 The Constitution of the year III was adopted. France November 15–17, 1796 The battle of Arcola which was the decisive battle during Napoleon’s defeat. Arcole, Italy 1798 Napoleon persuaded the ruling to invade Egypt. Malta, Egypt, and Syria November 9,1799 Napoleon and Abbe Sieyes pulled off a coup in France. France February 9, 1801 The treaty peace between the French Republic and the Emperor and the Germanic Body. Lunà ©ville, France 1801 Napoleon made peace with the pope and reconciled h The differences between the state and the Catholic Church. Rome and Paris March 25,1802 The treaty of Amiens was signed. Amiens, France December 2, 1804 Napoleon crowned himself Emperor Paris October 21,1805 The battle of Trafalgar was a naval engagement fought by the Royal Navy. Atlantic Ocean, near Cà ¡diz, Spain, and the Straits of Gibraltar December 26,1805 The treaty of Pressburg agreement was signed. Bratislava (Pressburg) June–November 1812 The French Invasion of Russia began. Russia October 16–19, 1813 The battle of Leipzig was fought by the coalition armies. Leipzig, Germany April 11, 1814 The treaty of Fontainebleau was signed. Paris March 20, 1815 The treaty of Paris was signed. France June 15,1815 Napoleon suffered defeat at the hands of Duke of Wellington and bringing an end to the Napoleonic era of European history. Waterloo, Belgium May 5, 1821 Napoleon dies as a British prisoner. Saint Helena, South Atlantic References Kishlansky, M., Geary, P., & O’Brien, P. (2010). Civilization in the West (2nd ed.). Upper Saddle River, New Jersey: Pearson Education, Inc.